Sion Kim Harris, PhD CPH, is an Associate Professor of Pediatrics at Harvard Medical School, and Co-Director, with Dr. John Rogers Knight, Jr., of the Boston Children’s Hospital Center for Adolescent Substance Abuse Research (CeASAR). Drs. Harris and Knight have worked together since CeASAR’s inception in 1999, conducting pioneering research in adolescent substance use screening and brief intervention strategies for use in medical offices, including the development and validation of the CRAFFT screen which has become the most widely studied and recommended screening tool for problematic adolescent substance use. They published the first large, multi-site international trial of computer-facilitated screening and clinician brief advice for adolescent alcohol and drug use in primary care. This study was conducted in two countries and involved 20 pediatric and family practices, demonstrating CeASAR’s ability to successfully complete multi-site studies in real-world medical office settings. Drs. Harris and Knight are currently Co-Principal Investigators of two NIAAA-funded studies conducted in primary care, one testing the validity of the new NIAAA brief alcohol screen for children and adolescents, and the other a pilot study of a new computerized brief motivational enhancement intervention for adolescents screening positive for substance use problems. CeASAR has conducted research in partnership with investigators worldwide including the Czech Republic, Spain, Brazil, and Colombia. Dr. Harris has published over 50 original scientific publications, and has received numerous awards, including the Young Professional Award from the Maternal and Child Health Section of the American Public Health Association, the John Nelson Chappel Best Research Award from the Association for Medical Education and Research in Substance Abuse, and the Estherann Grace Teaching Award and T. Berry Brazelton Innovation Award from the Boston Children’s Hospital Division of Adolescent/Young Adult Medicine, and Division of Developmental Medicine, respectively. She received her doctorate from the Johns Hopkins Bloomberg School of Public Health.